Therapeutic use of infliximab in tuberculosis to control severe paradoxical reaction of the brain and lymph nodes

Clin Infect Dis. 2008 Nov 15;47(10):e83-5. doi: 10.1086/592695.

Abstract

Paradoxical reactions are immune-mediated exacerbations of disease triggered by tuberculosis treatment. Paradoxical reactions involving the central nervous system may be life threatening. Infliximab (tumor necrosis factor antibody) profoundly inhibits cellular immune responses to Mycobacterium tuberculosis. We describe a case in which infliximab was used to control steroid-resistant tuberculosis paradoxical reaction involving the central nervous system.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Inflammatory Agents / therapeutic use*
  • Antibodies, Monoclonal / therapeutic use*
  • Brain / drug effects
  • Brain / immunology*
  • Brain / pathology
  • Female
  • Head / diagnostic imaging
  • Humans
  • Immunologic Factors / therapeutic use*
  • Infliximab
  • Lymph Nodes / drug effects
  • Lymph Nodes / immunology*
  • Lymph Nodes / pathology
  • Mycobacterium tuberculosis / immunology
  • Radiography
  • Steroids / therapeutic use
  • Tuberculosis / drug therapy*

Substances

  • Anti-Inflammatory Agents
  • Antibodies, Monoclonal
  • Immunologic Factors
  • Steroids
  • Infliximab