Abstract
In a murine model of disseminated zygomycosis, low doses of amphotericin B (0.3 mg/kg body weight/day) combined with posaconazole (40 mg/kg/day) prolonged survival and reduced tissue burden with respect to that of controls and that of both drugs administered alone. Results were similar to those obtained with amphotericin B given alone at 0.8 mg/kg/day.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphotericin B / administration & dosage*
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Animals
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Antifungal Agents / administration & dosage*
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Colony Count, Microbial
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Disease Models, Animal
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Drug Synergism
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Drug Therapy, Combination
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Humans
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Male
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Mice
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Mucormycosis / drug therapy*
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Mucormycosis / microbiology
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Rhizopus* / classification
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Rhizopus* / drug effects
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Rhizopus* / isolation & purification
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Rhizopus* / pathogenicity
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Triazoles / administration & dosage*
Substances
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Antifungal Agents
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Triazoles
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posaconazole
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Amphotericin B