Macrolide-resistant Shigella sonnei

Emerg Infect Dis. 2008 Aug;14(8):1297-9. doi: 10.3201/eid1408.080147.

Abstract

Shigella sonnei UCN59, isolated during an outbreak of S. sonnei in January 2007, was resistant to azithromycin (MIC 64 mg/L). The isolate contained a plasmid-borne mph(A) gene encoding a macrolide 2 -phosphotransferase that inactivates macrolides. Emergence of the mph(A) gene in S. sonnei may limit usefulness of azithromycin for treatment of shigellosis.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Child, Preschool
  • Disease Outbreaks
  • Drug Resistance, Multiple, Bacterial*
  • Dysentery, Bacillary / microbiology
  • Electrophoresis, Gel, Pulsed-Field
  • Female
  • Humans
  • Macrolides / pharmacology*
  • Phylogeny
  • Polymerase Chain Reaction
  • Shigella sonnei / drug effects*

Substances

  • Anti-Bacterial Agents
  • Macrolides