Evaluation of Etest method for determining isavuconazole MICs against Cryptococcus gattii and Cryptococcus neoformans

Antimicrob Agents Chemother. 2008 Aug;52(8):2959-61. doi: 10.1128/AAC.00646-08. Epub 2008 Jun 16.

Abstract

We compared Etest with broth microdilution testing for isavuconazole activity against 92 Cryptococcus isolates. A 97.8% agreement was found between these methods, without major discrepancies (>2-well dilution difference). Our findings support the use of the Etest methodology as a reliable method for the determination of MICs against Cryptococcus spp.

Publication types

  • Evaluation Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Antifungal Agents / pharmacology
  • Cryptococcus / drug effects*
  • Cryptococcus neoformans / drug effects*
  • Microbial Sensitivity Tests / methods*
  • Nitriles / pharmacology*
  • Pyridines / pharmacology*
  • Reproducibility of Results
  • Species Specificity
  • Triazoles / pharmacology*

Substances

  • Antifungal Agents
  • Nitriles
  • Pyridines
  • Triazoles
  • isavuconazole