Abstract
Three sets of novel 4-deoxy-l-arabinose analogs were synthesized and evaluated as potential inhibitors of the bacterial resistance mechanism in which lipid A, on the outer membrane, is modified with 4-amino-4-deoxy-l-arabinose (l-Ara4N). One compound diminished the transfer of l-Ara4N onto lipid A. These results suggest that small molecules might be designed that would effect the same reversal of bacterial resistance observed in genetic knockouts.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Arabinose / analogs & derivatives*
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Arabinose / chemical synthesis
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Arabinose / pharmacology
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Azides / chemical synthesis
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Azides / pharmacology
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Drug Resistance, Microbial
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Drug Synergism
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Hexosyltransferases / antagonists & inhibitors
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Lipid A / metabolism*
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Polymyxins / pharmacology*
Substances
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Anti-Bacterial Agents
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Azides
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Lipid A
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Polymyxins
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Arabinose
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Hexosyltransferases
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L-Ara4N transferase