Intestinal injury associated with spiramycin therapy of Cryptosporidium infection in AIDS

J Protozool. 1991 Nov-Dec;38(6):147S.

Abstract

Two of three patients treated with high doses of spiramycin for Cryptosporidium infection developed acute intestinal injury. Spiramycin at high doses may be directly toxic to the intestinal epithelium and thus may have limited utility as therapy for cryptosporidiosis in AIDS patients.

Publication types

  • Case Reports

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications*
  • Adult
  • Coccidiostats / adverse effects*
  • Coccidiostats / therapeutic use
  • Cryptosporidiosis / complications
  • Cryptosporidiosis / drug therapy*
  • Dose-Response Relationship, Drug
  • HIV Seropositivity / complications
  • Humans
  • Intestines / drug effects*
  • Male
  • Spiramycin / adverse effects*
  • Spiramycin / therapeutic use

Substances

  • Coccidiostats
  • Spiramycin