Granulomatous amoebic encephalitis caused by Acanthamoeba amoebae of genotype T2 in a human immunodeficiency virus-negative patient

J Clin Microbiol. 2008 Jan;46(1):338-40. doi: 10.1128/JCM.01177-07. Epub 2007 Nov 14.

Abstract

Acanthamoeba amoebae of genotype T2 were identified as the causative agent of Acanthamoeba skin lesions and granulomatous amoebic encephalitis (GAE) in a human immunodeficiency virus-negative patient with underlying tuberculosis. To our knowledge this, is the first case of GAE involving genotype T2.

Publication types

  • Case Reports

MeSH terms

  • Acanthamoeba / classification
  • Acanthamoeba / genetics
  • Acanthamoeba / isolation & purification*
  • Adult
  • Amebiasis / drug therapy
  • Amebiasis / parasitology
  • Amebiasis / pathology*
  • Amikacin / therapeutic use
  • Animals
  • Antiprotozoal Agents / therapeutic use
  • Antitubercular Agents / therapeutic use
  • DNA, Protozoan / chemistry
  • DNA, Protozoan / genetics
  • Encephalitis / drug therapy
  • Encephalitis / parasitology*
  • Encephalitis / pathology
  • Genotype
  • HIV Infections / complications
  • Humans
  • Male
  • Molecular Sequence Data
  • Phosphorylcholine / analogs & derivatives
  • Phosphorylcholine / therapeutic use
  • Sequence Analysis, DNA
  • Skin Diseases, Parasitic / parasitology
  • Skin Diseases, Parasitic / pathology
  • Tuberculosis / complications

Substances

  • Antiprotozoal Agents
  • Antitubercular Agents
  • DNA, Protozoan
  • Phosphorylcholine
  • miltefosine
  • Amikacin

Associated data

  • GENBANK/EF428121