Abstract
We describe a case of treatment failure caused by a strain of USA300 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with intermediate susceptibility to vancomycin and reduced susceptibility to daptomycin. The strain was isolated from the bone of a 56-year-old man with lumbar osteomyelitis after a 6-week treatment course of vancomycin for catheter-associated septic thrombophlebitis.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Community-Acquired Infections / drug therapy
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Community-Acquired Infections / microbiology
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Daptomycin / pharmacology
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Humans
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Lumbar Vertebrae / microbiology
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Male
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Methicillin / pharmacology*
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Methicillin Resistance
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Microbial Sensitivity Tests
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Middle Aged
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Osteomyelitis / drug therapy
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Osteomyelitis / microbiology
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Staphylococcal Infections / drug therapy
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Staphylococcal Infections / microbiology*
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / isolation & purification
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Thrombophlebitis / drug therapy
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Treatment Outcome
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Vancomycin / pharmacology*
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Vancomycin / therapeutic use
Substances
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Anti-Bacterial Agents
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Vancomycin
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Daptomycin
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Methicillin