Infective endocarditis due to community-associated methicillin-resistant Staphylococcus aureus in injection drug users may be associated with Panton-Valentine leukocidin-negative strains

Constantine Tsigrelis; Matthew D Armstrong; Nicholas E Vlahakis; John A Batsis; Larry M Baddour

doi:10.1080/00365540601003803

Infective endocarditis due to community-associated methicillin-resistant Staphylococcus aureus in injection drug users may be associated with Panton-Valentine leukocidin-negative strains

Scand J Infect Dis. 2007;39(4):299-302. doi: 10.1080/00365540601003803.

Authors

Constantine Tsigrelis¹, Matthew D Armstrong, Nicholas E Vlahakis, John A Batsis, Larry M Baddour

Affiliation

¹ Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. tsigrelis.constantine@mayo.edu

PMID: 17454892
DOI: 10.1080/00365540601003803

Abstract

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) isolates that cause infective endocarditis in injection drug users (IDUs) are distinct from CA-MRSA strains that cause endocardial infection as a complication of skin and soft tissue infections. We present a case of CA-MRSA infective endocarditis, review pertinent cases previously published, and describe the molecular characteristics of strains from IDUs and patients with skin and soft tissue infections.

Publication types

Case Reports
Review

MeSH terms

Adult
Community-Acquired Infections / microbiology
Endocarditis, Bacterial / drug therapy
Endocarditis, Bacterial / microbiology*
Endocarditis, Bacterial / surgery
Humans
Male
Methicillin Resistance*
Staphylococcal Infections / drug therapy
Staphylococcal Infections / microbiology*
Staphylococcal Infections / surgery
Staphylococcus aureus / classification
Staphylococcus aureus / drug effects*
Staphylococcus aureus / pathogenicity*
Substance Abuse, Intravenous / microbiology*
Tricuspid Valve / microbiology