Combined therapies in a murine model of blastoschizomycosis

Antimicrob Agents Chemother. 2007 Jul;51(7):2608-10. doi: 10.1128/AAC.00173-07. Epub 2007 Apr 23.

Abstract

In a murine model of blastoschizomycosis, amphotericin B combined with micafungin, flucytosine or voriconazole did not improve the efficacy of fluconazole. However, such combinations can constitute therapeutic options for those cases where fluconazole fails.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphotericin B / therapeutic use
  • Animals
  • Antifungal Agents / therapeutic use*
  • Colony Count, Microbial
  • Disease Models, Animal
  • Drug Synergism
  • Drug Therapy, Combination
  • Echinocandins
  • Flucytosine / therapeutic use
  • Geotrichosis / drug therapy*
  • Geotrichum / drug effects*
  • Humans
  • Immunocompromised Host
  • Lipopeptides
  • Lipoproteins / therapeutic use
  • Male
  • Micafungin
  • Mice
  • Mice, Inbred Strains
  • Microbial Sensitivity Tests
  • Mycoses / drug therapy*
  • Peptides, Cyclic / therapeutic use
  • Pyrimidines / therapeutic use
  • Survival Analysis
  • Triazoles / therapeutic use
  • Trichosporon / drug effects*
  • Voriconazole

Substances

  • Antifungal Agents
  • Echinocandins
  • Lipopeptides
  • Lipoproteins
  • Peptides, Cyclic
  • Pyrimidines
  • Triazoles
  • Amphotericin B
  • Flucytosine
  • Voriconazole
  • Micafungin