Abstract
We examined the capacity of Staphylococcus aureus strains to release Panton-Valentine leukocidin (PVL) in the presence of antibiotics. No PVL was detected when S. aureus was incubated at inhibitory concentrations, while subinhibitory concentrations of oxacillin enhanced the PVL level; clindamycin, linezolid, and fusidic acid were inhibitory; and vancomycin had roughly no effect.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacterial Toxins / biosynthesis
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Bacterial Toxins / metabolism*
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Exotoxins / biosynthesis*
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Leukocidins / biosynthesis*
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Microbial Sensitivity Tests
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / genetics
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Staphylococcus aureus / metabolism
Substances
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Anti-Bacterial Agents
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Bacterial Toxins
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Exotoxins
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Leukocidins
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Panton-Valentine leukocidin