Abstract
This study assessed daily aspirate samples from an indwelling sinus catheter during high-dose, short-course levofloxacin (750 mg daily x 5 days) treatment of acute maxillary sinusitis. Pathogens were isolated from 4 of 18 recruited patients. Bacteriologic eradication occurred within 24 h for 3 patients and 72 h for the 4th.
Publication types
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Clinical Trial
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Multicenter Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Adult
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Anti-Bacterial Agents / administration & dosage*
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Anti-Bacterial Agents / adverse effects
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Anti-Bacterial Agents / therapeutic use
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Catheters, Indwelling*
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Female
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Haemophilus Infections / drug therapy
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Haemophilus Infections / microbiology
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Haemophilus influenzae / drug effects
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Haemophilus influenzae / isolation & purification
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Humans
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Levofloxacin*
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Male
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Maxillary Sinusitis / drug therapy*
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Maxillary Sinusitis / microbiology*
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Microbial Sensitivity Tests
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Middle Aged
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Moraxella catarrhalis / drug effects
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Moraxella catarrhalis / isolation & purification
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Moraxellaceae Infections / drug therapy
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Moraxellaceae Infections / microbiology
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Ofloxacin / administration & dosage*
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Ofloxacin / adverse effects
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Ofloxacin / therapeutic use
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Pneumococcal Infections / drug therapy
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Pneumococcal Infections / microbiology
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Streptococcus pneumoniae / drug effects
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Streptococcus pneumoniae / isolation & purification
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Time Factors
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Treatment Outcome
Substances
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Anti-Bacterial Agents
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Levofloxacin
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Ofloxacin