Abstract
Among 313 Enterobacteriaceae from the United States with a ciprofloxacin MIC of >/=0.25 microg/ml and reduced susceptibility to ceftazidime, aac(6')-Ib was present in 50.5% of isolates, and of these, 28% carried the cr variant responsible for low-level ciprofloxacin resistance. aac(6')-Ib-cr was geographically widespread, stable over time, most common in Escherichia coli, equally prevalent in ciprofloxacin-susceptible and -resistant strains, and not associated with qnr genes.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Acetyltransferases / genetics*
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Anti-Bacterial Agents / metabolism*
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Ciprofloxacin / metabolism*
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Cross-Sectional Studies
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Drug Resistance, Bacterial / genetics
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Enterobacteriaceae / enzymology
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Enterobacteriaceae / genetics
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Enterobacteriaceae Infections / epidemiology
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Enterobacteriaceae Infections / microbiology
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Escherichia coli / drug effects
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Klebsiella pneumoniae / drug effects
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Microbial Sensitivity Tests
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Odds Ratio
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United States / epidemiology
Substances
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Anti-Bacterial Agents
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Ciprofloxacin
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Acetyltransferases
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aminoglycoside 2'-N-acetyltransferase