Use of esmolol to control autonomic instability of tetanus

Am J Med. 1991 Oct;91(4):425-8. doi: 10.1016/0002-9343(91)90162-q.

Abstract

Tetanus is often accompained by autonomic instability, rendering hemodynamic management difficult. Death is frequently secondary to an inability to control this instability. A variety of modalities have been used to stabilize the cardiovascular system, but all are not ideal. Esmolol offers theoretical advantages over other modalities. We report a case of severe tetanus in which a continuous infusion of esmolol was effective in controlling the autonomic instability.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic beta-Antagonists / administration & dosage
  • Adrenergic beta-Antagonists / pharmacology
  • Adrenergic beta-Antagonists / therapeutic use*
  • Adult
  • Autonomic Nervous System Diseases / drug therapy*
  • Autonomic Nervous System Diseases / etiology
  • Autonomic Nervous System Diseases / physiopathology
  • Drug Therapy, Combination
  • Female
  • Humans
  • Infusions, Intravenous
  • Norepinephrine / administration & dosage
  • Norepinephrine / therapeutic use
  • Propanolamines / administration & dosage
  • Propanolamines / pharmacology
  • Propanolamines / therapeutic use*
  • Tetanus / complications*

Substances

  • Adrenergic beta-Antagonists
  • Propanolamines
  • esmolol
  • Norepinephrine