Abstract
Linezolid in combination with ertapenem showed in vitro synergy against methicillin-resistant Staphylococcus aureus strains. We confirmed this interaction in vivo by using a rabbit endocarditis experimental model and simulation of the human pharmacokinetics in animals for both antibiotics. Linezolid plus ertapenem exhibited highly synergistic activity in vivo after 4 days of treatment.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetamides* / administration & dosage
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Acetamides* / pharmacokinetics
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Acetamides* / pharmacology
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Acetamides* / therapeutic use
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Animals
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Anti-Infective Agents* / administration & dosage
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Anti-Infective Agents* / pharmacology
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Anti-Infective Agents* / therapeutic use
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Drug Synergism
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Endocarditis, Bacterial* / drug therapy
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Endocarditis, Bacterial* / microbiology
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Ertapenem
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Humans
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Linezolid
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Methicillin Resistance*
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Oxazolidinones* / administration & dosage
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Oxazolidinones* / pharmacokinetics
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Oxazolidinones* / pharmacology
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Oxazolidinones* / therapeutic use
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Rabbits
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Staphylococcal Infections / drug therapy
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Staphylococcus aureus / drug effects*
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beta-Lactams* / administration & dosage
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beta-Lactams* / pharmacokinetics
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beta-Lactams* / pharmacology
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beta-Lactams* / therapeutic use
Substances
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Acetamides
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Anti-Infective Agents
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Oxazolidinones
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beta-Lactams
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Ertapenem
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Linezolid