Efficacy of cotrimoxazole and rifampin for 6 or 8 weeks of therapy in childhood brucellosis

Pediatr Infect Dis J. 2006 Jun;25(6):544-5. doi: 10.1097/01.inf.0000219403.91975.ce.

Abstract

From March 1998 to September 2001, 64 children and from October 2001 to December 2004, 66 children < or = 15 years with brucellosis in Babol, Iran, were treated with cotrimoxazole and rifampin for 6 or 8 weeks, respectively. Cure rate for 6 weeks was 89.1% and for 8 weeks it was 95.5%. Six weeks of therapy with cotrimoxazole plus rifampin is sufficient for treatment of childhood brucellosis.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Brucellosis / diagnosis*
  • Brucellosis / drug therapy*
  • Child
  • Child, Preschool
  • Cohort Studies
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Female
  • Follow-Up Studies
  • Humans
  • Iran
  • Male
  • Retrospective Studies
  • Rifampin / administration & dosage*
  • Risk Assessment
  • Severity of Illness Index
  • Treatment Outcome
  • Trimethoprim, Sulfamethoxazole Drug Combination / administration & dosage*

Substances

  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Rifampin