Listeria monocytogenes: a multifaceted model

Nat Rev Microbiol. 2006 Jun;4(6):423-34. doi: 10.1038/nrmicro1413.

Abstract

The opportunistic intracellular pathogen Listeria monocytogenes has become a paradigm for the study of host-pathogen interactions and bacterial adaptation to mammalian hosts. Analysis of L. monocytogenes infection has provided considerable insight into how bacteria invade cells, move intracellularly, and disseminate in tissues, as well as tools to address fundamental processes in cell biology. Moreover, the vast amount of knowledge that has been gathered through in-depth comparative genomic analyses and in vivo studies makes L. monocytogenes one of the most well-studied bacterial pathogens.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actins / metabolism
  • Adaptation, Physiological / genetics
  • Adaptation, Physiological / physiology
  • Animals
  • Bacterial Proteins / physiology
  • Endocytosis / genetics
  • Endocytosis / physiology
  • Gene Expression Regulation, Bacterial / genetics
  • Gene Expression Regulation, Bacterial / physiology
  • Genomics
  • Humans
  • Intercellular Junctions / genetics
  • Intercellular Junctions / metabolism
  • Listeria monocytogenes / genetics
  • Listeria monocytogenes / pathogenicity*
  • Listeria monocytogenes / physiology*
  • Listeriosis / microbiology*
  • Listeriosis / physiopathology
  • Membrane Proteins / physiology*
  • Mice
  • Signal Transduction / physiology
  • Virulence Factors / genetics

Substances

  • Actins
  • Bacterial Proteins
  • Membrane Proteins
  • Virulence Factors
  • internalin protein, Bacteria