Abstract
Polyomavirus BK is a significant pathogen in transplant recipients, but no effective antiviral therapy is available. We show that cidofovir can inhibit BK virus replication in vitro. Esterification of cidofovir with hexadecyloxypropyl, octadecyloxyethyl, and oleyloxyethyl groups results in up to a 3-log lowering of the 50% effective concentration and an increased selectivity index.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antiviral Agents / pharmacology*
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BK Virus / drug effects*
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BK Virus / physiology
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Cidofovir
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Cytosine / analogs & derivatives*
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Cytosine / pharmacokinetics
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Cytosine / pharmacology
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DNA, Viral / biosynthesis
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Esters / pharmacology
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Organophosphonates / pharmacokinetics
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Organophosphonates / pharmacology*
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Virus Replication / drug effects*
Substances
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Antiviral Agents
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DNA, Viral
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Esters
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Organophosphonates
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Cytosine
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Cidofovir