Abstract
The emergence of a clinically daptomycin-resistant Staphylococcus aureus isolate occurred during treatment of methicillin-resistant S. aureus bacteremia and probable vertebral osteomyelitis. The breakthrough isolate was indistinguishable from pretreatment daptomycin-susceptible isolates by pulsed-field gel electrophoresis. Daptomycin nonsusceptibility was confirmed by MIC and time-kill curve analyses.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use
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Bacteremia / drug therapy*
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Bacteremia / microbiology
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Daptomycin / pharmacology*
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Daptomycin / therapeutic use
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Drug Resistance, Bacterial*
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Electrophoresis, Gel, Pulsed-Field
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Humans
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Male
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Methicillin Resistance*
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Microbial Sensitivity Tests
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Middle Aged
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Osteomyelitis / drug therapy*
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Osteomyelitis / microbiology
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Staphylococcal Infections / drug therapy
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Staphylococcal Infections / microbiology
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Staphylococcus aureus / classification
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / genetics
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Staphylococcus aureus / isolation & purification
Substances
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Anti-Bacterial Agents
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Daptomycin