Abstract
This randomized, double-blind, placebo-controlled crossover study measured the effect of a single dose of oral gabapentin (900 mg) on pain and allodynia associated with herpes zoster. Pain severity decreased by 66% with gabapentin compared to 33% with placebo. Reductions in allodynia area and severity, and overall pain relief, were also greater with gabapentin.
Publication types
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Randomized Controlled Trial
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acute Disease / therapy
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Adult
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Aged
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Aged, 80 and over
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Amines / administration & dosage*
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Amines / therapeutic use
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Analgesics / administration & dosage
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Analgesics / therapeutic use
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Anticonvulsants / administration & dosage
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Anticonvulsants / therapeutic use
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Cross-Over Studies
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Cyclohexanecarboxylic Acids / administration & dosage*
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Cyclohexanecarboxylic Acids / therapeutic use
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Dose-Response Relationship, Drug
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Double-Blind Method
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Drug Administration Schedule
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Female
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Gabapentin
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Herpes Zoster / complications*
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Herpes Zoster / physiopathology
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Humans
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Hyperalgesia / drug therapy*
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Hyperalgesia / etiology
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Hyperalgesia / physiopathology
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Male
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Middle Aged
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Pain Measurement
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Pain Threshold / drug effects*
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Pain Threshold / physiology
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Treatment Outcome
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gamma-Aminobutyric Acid / administration & dosage*
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gamma-Aminobutyric Acid / therapeutic use
Substances
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Amines
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Analgesics
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Anticonvulsants
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Cyclohexanecarboxylic Acids
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gamma-Aminobutyric Acid
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Gabapentin