Cryptococcus neoformans Galactoxylomannan contains an epitope(s) that is cross-reactive with Aspergillus Galactomannan

Frédéric Dalle; Pierre Emmanuel Charles; Karine Blanc; Denis Caillot; Pascal Chavanet; Françoise Dromer; Alain Bonnin

doi:10.1128/JCM.43.6.2929-2931.2005

Cryptococcus neoformans Galactoxylomannan contains an epitope(s) that is cross-reactive with Aspergillus Galactomannan

J Clin Microbiol. 2005 Jun;43(6):2929-31. doi: 10.1128/JCM.43.6.2929-2931.2005.

Authors

Frédéric Dalle¹, Pierre Emmanuel Charles, Karine Blanc, Denis Caillot, Pascal Chavanet, Françoise Dromer, Alain Bonnin

Affiliation

¹ Laboratoire de Parasitologie Mycologie, Hôpital du Bocage, BP 77 908, 21079 Dijon Cedex, France.

Abstract

We report a case of cryptococcosis in which a serum enzyme-linked immunosorbent assay (ELISA) for Aspergillus galactomannan was positive, with no evidence of aspergillosis. Soluble antigens from 19 Cryptococcus neoformans strains and purified carbohydrates of C. neoformans capsule were thus assayed in the Aspergillus galactomannan ELISA. Antigens from all C. neoformans strains, and purified galactoxylomannan, gave a positive reaction, suggesting that C. neoformans galactoxylomannan contains an epitope(s) that is cross-reactive with Aspergillus galactomannan.

Publication types

Case Reports

MeSH terms

Adult
Aspergillus / immunology*
Aspergillus / metabolism
Cross Reactions
Cryptococcosis / immunology
Cryptococcosis / microbiology
Cryptococcus neoformans / immunology*
Cryptococcus neoformans / metabolism
Enzyme-Linked Immunosorbent Assay
Epitopes / chemistry
Epitopes / immunology*
Galactose / analogs & derivatives
Humans
Male
Mannans / immunology*
Polysaccharides
Polysaccharides, Bacterial / chemistry
Polysaccharides, Bacterial / immunology*

Substances

Epitopes
Mannans
Polysaccharides
Polysaccharides, Bacterial
galactomannan
galactoxylomannan
Galactose