Selection of cross-resistance following exposure of Pseudomonas aeruginosa clinical isolates to ciprofloxacin or cefepime

Samer A Alyaseen; Kerryl E Piper; Mark S Rouse; James M Steckelberg; Robin Patel

doi:10.1128/AAC.49.6.2543-2545.2005

Selection of cross-resistance following exposure of Pseudomonas aeruginosa clinical isolates to ciprofloxacin or cefepime

Antimicrob Agents Chemother. 2005 Jun;49(6):2543-5. doi: 10.1128/AAC.49.6.2543-2545.2005.

Authors

Samer A Alyaseen¹, Kerryl E Piper, Mark S Rouse, James M Steckelberg, Robin Patel

Affiliation

¹ Division of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine, 200 First St. SW, Rochester, MN 55905, USA.

Abstract

Exposure of ciprofloxacin- and cefepime-susceptible Pseudomonas aeruginosa isolates to increasing concentrations of ciprofloxacin selected for ciprofloxacin resistance in 26/27 and cefepime nonsusceptibility in 7/27 isolates. Exposure of the isolates to increasing concentrations of cefepime selected for cefepime nonsusceptibility in 20/27 isolates but not for ciprofloxacin resistance.

Publication types

Comparative Study

MeSH terms

Anti-Infective Agents / pharmacology*
Cefepime
Cephalosporin Resistance / genetics*
Cephalosporins / pharmacology*
Ciprofloxacin / pharmacology*
Humans
Microbial Sensitivity Tests
Pseudomonas aeruginosa / drug effects*
Pseudomonas aeruginosa / genetics
Selection, Genetic*

Substances

Anti-Infective Agents
Cephalosporins
Ciprofloxacin
Cefepime