Abstract
Doripenem 50% inhibitory concentrations (MIC50) and 90% inhibitory concentrations (MIC90) for multidrug-resistant strains of mucoid Pseudomonas aeruginosa (n=200 strains), nonmucoid P. aeruginosa (n=200), and Burkholderia cepacia complex (n=200) isolated from patients with cystic fibrosis were 8 and 32, 8 and 64, and 8 and 32 microg/ml, respectively. Doripenem had somewhat better activity than established antimicrobial agents.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Burkholderia Infections / microbiology
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Burkholderia cepacia complex / drug effects*
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Burkholderia cepacia complex / isolation & purification
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Carbapenems / pharmacology*
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Cystic Fibrosis / microbiology*
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Doripenem
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Drug Resistance, Multiple, Bacterial*
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Humans
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Microbial Sensitivity Tests
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Pseudomonas Infections / microbiology
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / isolation & purification
Substances
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Anti-Bacterial Agents
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Carbapenems
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Doripenem