Prevalence of derepressed ampC mutants and extended-spectrum beta-lactamase producers among clinical isolates of Citrobacter freundii, Enterobacter spp., and Serratia marcescens in Korea: dissemination of CTX-M-3, TEM-52, and SHV-12

J Clin Microbiol. 2005 May;43(5):2452-5. doi: 10.1128/JCM.43.5.2452-2455.2005.

Abstract

The resistance mechanism of extended-spectrum cephalosporins in clinical isolates of Citrobacter freundii, Enterobacter spp., and Serratia marcescens was studied. Of 152 isolates, 45 isolates (29.6%) were derepressed AmpC mutants and 39 isolates (25.7%) produced extended-spectrum beta-lactamase (ESBLs). The most prevalent ESBLs were CTX-M enzymes, followed by TEM-52 and SHV-12.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / genetics*
  • Base Sequence
  • Cephalosporins / pharmacology
  • Citrobacter / classification
  • Citrobacter / enzymology
  • Citrobacter / genetics*
  • Citrobacter / isolation & purification
  • DNA Primers
  • Enterobacter / classification
  • Enterobacter / enzymology
  • Enterobacter / genetics*
  • Enterobacter / isolation & purification
  • Humans
  • Korea
  • Microbial Sensitivity Tests
  • Serratia marcescens / classification
  • Serratia marcescens / enzymology
  • Serratia marcescens / genetics*
  • Serratia marcescens / isolation & purification
  • beta-Lactamases / genetics*

Substances

  • Bacterial Proteins
  • Cephalosporins
  • DNA Primers
  • AmpC beta-lactamases
  • beta-Lactamases