Abstract
The resistance mechanism of extended-spectrum cephalosporins in clinical isolates of Citrobacter freundii, Enterobacter spp., and Serratia marcescens was studied. Of 152 isolates, 45 isolates (29.6%) were derepressed AmpC mutants and 39 isolates (25.7%) produced extended-spectrum beta-lactamase (ESBLs). The most prevalent ESBLs were CTX-M enzymes, followed by TEM-52 and SHV-12.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / genetics*
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Base Sequence
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Cephalosporins / pharmacology
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Citrobacter / classification
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Citrobacter / enzymology
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Citrobacter / genetics*
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Citrobacter / isolation & purification
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DNA Primers
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Enterobacter / classification
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Enterobacter / enzymology
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Enterobacter / genetics*
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Enterobacter / isolation & purification
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Humans
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Korea
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Microbial Sensitivity Tests
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Serratia marcescens / classification
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Serratia marcescens / enzymology
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Serratia marcescens / genetics*
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Serratia marcescens / isolation & purification
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beta-Lactamases / genetics*
Substances
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Bacterial Proteins
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Cephalosporins
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DNA Primers
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AmpC beta-lactamases
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beta-Lactamases