Abstract
Molecular analysis of 63 Escherichia coli urine isolates showed that pyelonephritis (n=23) and prostatitis (n=17) isolates exhibited more virulence factors (VFs) among the 35 sought than did cystitis isolates (n=23). Several nontraditional VFs--including bmaE (M fimbriae), gafD (G fimbriae), fyuA (yersiniabactin receptor), ireA and iroN (novel siderophore receptors), cvaC (colicin [microcin] V), traT (serum-resistance associated), ibeA (invasion of brain endothelium), ompT (outer membrane protease T), and malX (pathogenicity island marker)--either differentiated significantly between syndromes (despite small numbers of isolates and possible multiple-comparison artifacts) or were broadly prevalent. Thus, interventions that target conserved uro-VFs may be possible, despite the likely existence of syndrome-specific pathogenetic mechanisms and/or host defense systems.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adhesins, Bacterial / genetics
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Adult
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Aged
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Bacterial Outer Membrane Proteins / genetics
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Bacteriocins / genetics
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Cystitis / microbiology*
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Escherichia coli / classification
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Escherichia coli / genetics*
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Escherichia coli / isolation & purification
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Escherichia coli / pathogenicity
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Escherichia coli Infections / microbiology*
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Escherichia coli Proteins / genetics
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Female
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Fimbriae Proteins / genetics
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Fimbriae, Bacterial / genetics
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Genomic Islands / genetics
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Humans
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Lectins / genetics
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Male
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Membrane Proteins / genetics
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Middle Aged
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Peptide Hydrolases
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Phenols / analysis
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Porins / genetics
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Prostatitis / microbiology*
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Pyelonephritis / microbiology*
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Receptors, Cell Surface / genetics
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Spain
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Thiazoles / analysis
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Urine / microbiology
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Virulence Factors / analysis
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Virulence Factors / genetics*
Substances
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Adhesins, Bacterial
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Bacterial Outer Membrane Proteins
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Bacteriocins
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CusC protein, E coli
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Escherichia coli Proteins
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GafD protein, E coli
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IreA protein, E coli
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Lectins
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Membrane Proteins
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Phenols
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Porins
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Receptors, Cell Surface
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Thiazoles
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TraT protein, E coli
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Virulence Factors
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ompT protein, E coli
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siderophore receptors
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yersiniabactin
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microcin
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Fimbriae Proteins
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Peptide Hydrolases