Abstract
The activity of daptomycin was assessed against 545 isolates of Gram-positive bacteria including enterococci, coagulase-positive and -negative staphylococci, beta-haemolytic streptococci, viridans streptococci and coryneforms. The panel of isolates was biased towards those with resistance to first-line antimicrobial agents and included linezolid-resistant enterococci and Staphylococcus aureus. MICs of daptomycin were < or =1mg/l for all the staphylococci, streptococci, and coryneforms, except for two isolates of Corynebacterium aquaticum, for which MICs were 8 mg/l. Daptomycin MICs were < or =2 and < or =4 mg/l for Enterococcus faecalis and Enterococcus faecium, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetamides / pharmacology*
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Anti-Bacterial Agents / pharmacology*
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Anti-Infective Agents / pharmacology*
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Daptomycin / pharmacology*
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Drug Resistance, Bacterial
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Drug Resistance, Multiple*
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Enterococcus / drug effects*
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Enterococcus / isolation & purification
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Gram-Positive Bacteria / drug effects*
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Gram-Positive Bacteria / isolation & purification
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Gram-Positive Bacterial Infections
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Humans
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Linezolid
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Oxazolidinones / pharmacology*
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / isolation & purification
Substances
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Acetamides
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Anti-Bacterial Agents
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Anti-Infective Agents
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Oxazolidinones
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Linezolid
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Daptomycin