Successful treatment of methicillin-resistant Staphylococcus aureus endocarditis with linezolid

Int J Antimicrob Agents. 2004 Jul;24(1):83-4. doi: 10.1016/j.ijantimicag.2003.12.018.

Abstract

We report the successful treatment with linezolid of a methicillin-resistant Staphylococcus aureus (MRSA) endocarditis in a patient with a severe allergic reaction to glycopeptides. Linezolid is a drug with well-recognised activity against S. aureus and proved to be efficacious even in the unusual site of heart valves. This drug could be a good therapeutic choice when glycopeptides treatment is not feasible.

MeSH terms

  • Acetamides / therapeutic use*
  • Anti-Infective Agents / therapeutic use*
  • Endocarditis, Bacterial / drug therapy*
  • Endocarditis, Bacterial / microbiology
  • Humans
  • Linezolid
  • Methicillin Resistance*
  • Oxazolidinones / therapeutic use*
  • Staphylococcal Infections / drug therapy*
  • Staphylococcal Infections / microbiology
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / isolation & purification

Substances

  • Acetamides
  • Anti-Infective Agents
  • Oxazolidinones
  • Linezolid