Abstract
A 4 1/2-month-old, 26-week premature infant with multiple complications of prematurity required a central venous catheter for venous access and antibiotic treatment of bacterial nosocomial infections. He developed tricuspid valve endocarditis with vegetation caused by Enterococcus faecium resistant to ampicillin, vancomycin and quinupristin-dalfopristin but susceptible to linezolid. He was successfully treated with linezolid intravenously (7 weeks) and then orally (2 weeks).
MeSH terms
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Acetamides / administration & dosage*
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Anti-Infective Agents / administration & dosage
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Endocarditis, Bacterial / drug therapy*
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Endocarditis, Bacterial / microbiology
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Enterococcus faecium / drug effects*
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Enterococcus faecium / isolation & purification
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Follow-Up Studies
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Gram-Positive Bacterial Infections / drug therapy*
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Gram-Positive Bacterial Infections / microbiology
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Humans
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Infant
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Infant, Newborn
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Infant, Premature*
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Infusions, Intravenous
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Linezolid
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Male
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Microbial Sensitivity Tests
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Oxazolidinones / administration & dosage*
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Risk Assessment
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Treatment Outcome
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Vancomycin Resistance
Substances
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Acetamides
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Anti-Infective Agents
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Oxazolidinones
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Linezolid