Once-weekly dalbavancin versus standard-of-care antimicrobial regimens for treatment of skin and soft-tissue infections

Clin Infect Dis. 2003 Nov 15;37(10):1298-303. doi: 10.1086/379015. Epub 2003 Oct 17.

Abstract

Dalbavancin, a novel glycopeptide with a long elimination half-life ( approximately 9-12 days), was compared to standard antimicrobial therapy for skin and soft-tissue infections (SSTIs). In a randomized, controlled, open-label, phase 2 proof-of-concept trial, adults received 1100 mg of dalbavancin (as a single intravenous infusion), 1000 mg of dalbavancin intravenously and then 500 mg intravenously 1 week later, or a prospectively defined standard-of-care regimen. A gram-positive pathogen was isolated from samples obtained from 41 (66%) of 62 patients at baseline; Staphylococcus aureus was the most prevalent species (83% of pathogens). Clinical success rates at a follow-up visit (test of cure) were 94.1% among patients treated with 2 doses of dalbavancin, 61.5% among patients treated with 1 dose of dalbavancin, and 76.2% among patients treated with a standard-of-care regimen. All treatment regimens were well tolerated; drug-related adverse reaction rates were similar across the 3 groups. These findings suggest that a regimen of 2 doses of dalbavancin administered 1 week apart is effective in the treatment of complicated, gram-positive bacterial SSTIs and warrants further study.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anti-Infective Agents / adverse effects
  • Anti-Infective Agents / therapeutic use*
  • Drug Tolerance
  • Female
  • Glycopeptides / adverse effects
  • Glycopeptides / therapeutic use*
  • Humans
  • Male
  • Skin Diseases, Infectious / drug therapy*
  • Skin Diseases, Infectious / microbiology
  • Soft Tissue Infections / drug therapy*
  • Soft Tissue Infections / microbiology
  • Staphylococcus aureus
  • Teicoplanin / analogs & derivatives
  • Treatment Outcome

Substances

  • Anti-Infective Agents
  • Glycopeptides
  • Teicoplanin
  • dalbavancin