Malignant otitis externa: the therapeutic evolution of a lethal infection

J Antimicrob Chemother. 1992 Dec;30(6):745-51. doi: 10.1093/jac/30.6.745.

Abstract

Malignant otitis externa (MOE) is a potentially fatal infection of the external auditory canal caused by Pseudomonas aeruginosa in a majority of cases. Treatment of MOE has changed over the years. Surgical debridement of all infected tissue is no longer considered the treatment of choice and has been replaced by localized surgical debridement supplemented with long-term antimicrobial chemotherapy. The recent availability of the fluoroquinolones and in particular ciprofloxacin has opened up new therapeutic opportunities.

Publication types

  • Review

MeSH terms

  • Aminoglycosides
  • Anti-Bacterial Agents / therapeutic use
  • Anti-Infective Agents / therapeutic use*
  • Cephalosporins / therapeutic use
  • Fluoroquinolones
  • Humans
  • Otitis Externa / drug therapy*
  • Otitis Externa / microbiology
  • Otitis Externa / mortality
  • Pseudomonas Infections / drug therapy*
  • Pseudomonas Infections / mortality

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Cephalosporins
  • Fluoroquinolones