Susceptibility of Rickettsia conorii, R. rickettsii, and Coxiella burnetii to PD 127,391, PD 131,628, pefloxacin, ofloxacin, and ciprofloxacin

Antimicrob Agents Chemother. 1992 Nov;36(11):2529-32. doi: 10.1128/AAC.36.11.2529.

Abstract

Plaque formation and dye uptake assays were used to measure the MICs of PD 127,391 and PD 131,628 against Rickettsia species. The MICs of PD 127,391 were 0.25 microgram/ml for Rickettsia rickettsii and 0.125 to 0.25 microgram/ml for Rickettsia conorii. The MICs of PD 131,628 were 0.25 to 0.5 microgram/ml for R. rickettsii and 0.5 microgram/ml for R. conorii. As determined by the shell vial technique, 15 strains of Coxiella burnetii were susceptible to PD 127,391 and PD 131,628 (MIC, < or = 1 microgram/ml), while one strain of C. burnetii (MP10) was of intermediate susceptibility.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / pharmacology*
  • Ciprofloxacin / pharmacology
  • Coxiella burnetii / drug effects*
  • Fluoroquinolones*
  • Microbial Sensitivity Tests
  • Naphthyridines*
  • Ofloxacin / pharmacology
  • Pefloxacin / pharmacology
  • Quinolones / pharmacology
  • Rickettsia / drug effects*
  • Rickettsia rickettsii / drug effects*
  • Viral Plaque Assay

Substances

  • Anti-Infective Agents
  • Fluoroquinolones
  • Naphthyridines
  • Quinolones
  • PD 131628
  • Pefloxacin
  • Ciprofloxacin
  • clinafloxacin
  • Ofloxacin