Cytomegalovirus (CMV) pneumonitis in AIDS patients: the result of intensive CMV replication?

P Aukrust; I N Farstad; S S Frøland; E Holter

Cytomegalovirus (CMV) pneumonitis in AIDS patients: the result of intensive CMV replication?

Eur Respir J. 1992 Mar;5(3):362-4.

Authors

P Aukrust¹, I N Farstad, S S Frøland, E Holter

Affiliation

¹ Medical Dept A, University of Oslo, National Hospital, Norway.

PMID: 1315296

Abstract

We report a case of fatal pulmonary disease in a patient infected with human immunodeficiency virus (HIV), where cytomegalovirus (CMV) was the only causative agent identified in the lungs at autopsy. The most prominent histopathological features were numerous interalveolar cells containing CMV inclusion bodies combined with scanty signs of inflammation. We propose that the lung damage caused by CMV in acquired immune deficiency syndrome (AIDS) patients is a direct consequence of cytopathogenic effects of the virus related to the extent of active virus replication.

Publication types

Case Reports

MeSH terms

Acquired Immunodeficiency Syndrome / complications*
Acquired Immunodeficiency Syndrome / microbiology
Acquired Immunodeficiency Syndrome / pathology
Adult
Cytomegalovirus / isolation & purification
Cytomegalovirus / pathogenicity*
Cytomegalovirus / physiology
Cytomegalovirus Infections / etiology*
Cytomegalovirus Infections / microbiology
Cytomegalovirus Infections / pathology
Cytopathogenic Effect, Viral / physiology
Humans
Inclusion Bodies, Viral / ultrastructure
Lung / microbiology*
Lung / pathology
Lung / ultrastructure
Male
Opportunistic Infections / etiology*
Opportunistic Infections / microbiology
Opportunistic Infections / pathology
Pneumonia, Viral / etiology*
Pneumonia, Viral / microbiology
Pneumonia, Viral / pathology
Virus Replication / physiology*