Immunopathogenesis and immunotherapy in AIDS virus infections

Norman L Letvin; Bruce D Walker

doi:10.1038/nm0703-861

Immunopathogenesis and immunotherapy in AIDS virus infections

Nat Med. 2003 Jul;9(7):861-6. doi: 10.1038/nm0703-861.

Authors

Norman L Letvin¹, Bruce D Walker

Affiliation

¹ Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

PMID: 12835706
DOI: 10.1038/nm0703-861

Abstract

The heterogeneity of HIV and the different human leukocyte antigen (HLA) backgrounds of infected individuals have posed challenges to understanding the pathogenesis of HIV infection. But continuing advances in our knowledge of the role of immune responses in controlling HIV viremia should help to define goals for immune-based therapies and vaccine strategies against AIDS.

Publication types

Review

MeSH terms

Acquired Immunodeficiency Syndrome / immunology*
Acquired Immunodeficiency Syndrome / therapy*
Antibodies / immunology
HIV Infections / immunology*
HIV-1 / immunology*
HIV-1 / pathogenicity*
HLA Antigens / immunology*
Humans
Immunotherapy / methods*
T-Lymphocytes, Cytotoxic / immunology
T-Lymphocytes, Cytotoxic / virology

Substances

Antibodies
HLA Antigens