Abstract
We studied the anti-Aspergillus activity of micafungin by using two fluorescent dyes to detect cell viability. Micafungin induced flattened hyphae, caused by the bursting of cells, which had lost their viability. Micafungin has killing activity against actively growing hyphae, even though it is not fungicidal against the whole burden of Aspergillus fumigatus.
MeSH terms
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Antifungal Agents / pharmacology*
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Aspergillus fumigatus / drug effects*
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Aspergillus fumigatus / growth & development
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Aspergillus fumigatus / metabolism
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Barbiturates / metabolism
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Echinocandins
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Fluoresceins / metabolism
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Fluorescent Dyes
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Hyphae / drug effects
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Hyphae / growth & development
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Hyphae / metabolism
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Isoxazoles / metabolism
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Lipopeptides
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Lipoproteins / pharmacology*
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Micafungin
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Microscopy, Fluorescence
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Microscopy, Interference
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Peptides, Cyclic / pharmacology*
Substances
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Antifungal Agents
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Barbiturates
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Echinocandins
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Fluoresceins
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Fluorescent Dyes
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Isoxazoles
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Lipopeptides
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Lipoproteins
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Peptides, Cyclic
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bis(1,3-dibutylbarbiturate)trimethine oxonol
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5-carboxyfluorescein diacetate
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Micafungin