Influences of linezolid, penicillin, and clindamycin, alone and in combination, on streptococcal pyrogenic exotoxin a release

Antimicrob Agents Chemother. 2003 May;47(5):1752-5. doi: 10.1128/AAC.47.5.1752-1755.2003.

Abstract

An in vitro model was used to compare the effects of linezolid, clindamycin, and penicillin, alone and in combination, on streptococcal pyrogenic exotoxin A (SPE A) release against virulent group A streptococci (GAS). All regimens exhibited lower (P < 0.05) SPE A release at 1 h than those with penicillin alone. Linezolid and clindamycin, alone or in combination with penicillin, may optimize the treatment of GAS infections by reducing bacterial burden and exotoxin release.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetamides / pharmacology*
  • Bacterial Proteins*
  • Clindamycin / pharmacology*
  • Drug Therapy, Combination / pharmacology*
  • Exotoxins / metabolism*
  • Humans
  • Linezolid
  • Membrane Proteins*
  • Oxazolidinones / pharmacology*
  • Penicillins / pharmacology*
  • Streptococcal Infections / drug therapy
  • Streptococcus pyogenes / drug effects*
  • Streptococcus pyogenes / pathogenicity

Substances

  • Acetamides
  • Bacterial Proteins
  • Exotoxins
  • Membrane Proteins
  • Oxazolidinones
  • Penicillins
  • SpeA protein, Streptococcus pyogenes
  • erythrogenic toxin
  • Clindamycin
  • Linezolid