Abstract
An in vitro model was used to compare the effects of linezolid, clindamycin, and penicillin, alone and in combination, on streptococcal pyrogenic exotoxin A (SPE A) release against virulent group A streptococci (GAS). All regimens exhibited lower (P < 0.05) SPE A release at 1 h than those with penicillin alone. Linezolid and clindamycin, alone or in combination with penicillin, may optimize the treatment of GAS infections by reducing bacterial burden and exotoxin release.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetamides / pharmacology*
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Bacterial Proteins*
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Clindamycin / pharmacology*
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Drug Therapy, Combination / pharmacology*
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Exotoxins / metabolism*
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Humans
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Linezolid
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Membrane Proteins*
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Oxazolidinones / pharmacology*
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Penicillins / pharmacology*
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Streptococcal Infections / drug therapy
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Streptococcus pyogenes / drug effects*
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Streptococcus pyogenes / pathogenicity
Substances
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Acetamides
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Bacterial Proteins
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Exotoxins
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Membrane Proteins
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Oxazolidinones
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Penicillins
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SpeA protein, Streptococcus pyogenes
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erythrogenic toxin
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Clindamycin
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Linezolid