Endocarditis due to glycopeptide-intermediate Staphylococcus aureus: case report and strain characterization

Diagn Microbiol Infect Dis. 2003 Feb;45(2):149-52. doi: 10.1016/s0732-8893(02)00511-4.

Abstract

We report a case of infective endocarditis due to vancomycin-intermediate Staphylococcus aureus (VISA) that did not respond to high doses of vancomycin. Initial vancomycin MIC of the last isolate recovered from blood was 8 micro g/mL, but could be induced up to 32 micro g/mL by consecutive growing with vancomycin. Clinical response was only accomplished when linezolid was included in therapy.

Publication types

  • Case Reports

MeSH terms

  • Drug Resistance, Multiple, Bacterial
  • Endocarditis / drug therapy
  • Endocarditis / microbiology*
  • Female
  • Humans
  • Microbial Sensitivity Tests
  • Middle Aged
  • Oxacillin / pharmacology
  • Staphylococcal Infections / drug therapy
  • Staphylococcal Infections / microbiology*
  • Staphylococcus aureus / classification
  • Staphylococcus aureus / drug effects
  • Staphylococcus aureus / isolation & purification*
  • Vancomycin / pharmacology
  • Vancomycin / therapeutic use
  • Vancomycin Resistance*

Substances

  • Vancomycin
  • Oxacillin