Abstract
This retrospective cohort study revealed that linezolid resistance in vancomycin-resistant Enterococcus faecium was dependent on prior linezolid exposure and duration of linezolid therapy. These strains of E. faecium were resistant to the entire class of oxazolidinones.
MeSH terms
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Acetamides / pharmacology*
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Anti-Bacterial Agents / pharmacology
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Enterococcus faecium*
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Female
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Gram-Positive Bacterial Infections / epidemiology*
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Gram-Positive Bacterial Infections / microbiology
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Humans
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Linezolid
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Oxazolidinones / pharmacology*
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Risk Factors
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Vancomycin Resistance / physiology*
Substances
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Acetamides
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Anti-Bacterial Agents
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Oxazolidinones
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Linezolid