Abstract
We have examined the in vitro activities of fluconazole, amphotericin B, and caspofungin against Candida albicans biofilms by time-kill methodology. Fluconazole was ineffective against biofilms. Killing of biofilm cells was suboptimal at therapeutic concentrations of amphotericin B. Caspofungin displayed the most effective pharmacokinetic properties, with > or =99% killing at physiological concentrations.
MeSH terms
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Amphotericin B / pharmacology*
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / pharmacology*
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Biofilms
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Candida albicans / drug effects*
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Caspofungin
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Colony Count, Microbial
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Colorimetry
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Coloring Agents
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Echinocandins
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Fluconazole / pharmacology*
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Indicators and Reagents
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Lipopeptides
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Peptides*
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Peptides, Cyclic*
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Reproducibility of Results
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Tetrazolium Salts
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Time Factors
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Coloring Agents
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Echinocandins
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Indicators and Reagents
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Lipopeptides
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Peptides
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Peptides, Cyclic
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Tetrazolium Salts
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2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-((phenylamino)carbonyl)-2H-tetrazolium hydroxide
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Amphotericin B
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Fluconazole
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Caspofungin