Phenylpropenamide derivatives AT-61 and AT-130 inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro

Antimicrob Agents Chemother. 2002 Sep;46(9):3057-60. doi: 10.1128/AAC.46.9.3057-3060.2002.

Abstract

The phenylpropenamide derivatives AT-61 and AT-130 are nonnucleoside analogue inhibitors of hepatitis B virus (HBV) replication. They inhibited the replication of wild-type HBV with 50% inhibitory concentrations of 21.2 +/- 9.5 and 2.40 +/- 0.92 micro M, respectively, compared to 0.064 +/- 0.020 micro M lamivudine. There were no significant differences in sensitivity between wild-type and nucleoside analogue-resistant (rtL180M, rtM204I, and rtL180M + rtM204V) HBV.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / pharmacology*
  • Anti-HIV Agents / pharmacology*
  • Benzamides / pharmacology*
  • Benzene Derivatives / pharmacology*
  • Drug Resistance, Viral
  • Hepatitis B virus / drug effects*
  • Lamivudine / pharmacology*
  • Viral Plaque Assay
  • Virus Replication / drug effects*

Substances

  • AT 130
  • AT 61
  • Amides
  • Anti-HIV Agents
  • Benzamides
  • Benzene Derivatives
  • Lamivudine