Linezolid for the treatment of central nervous system infections in neurosurgical patients

Scand J Infect Dis. 2002;34(6):456-9. doi: 10.1080/00365540110080467.

Abstract

We report our experience with linezolid in the treatment of 5 patients with central nervous system infections subsequent to neurosurgical interventions. In all cases, initial antimicrobial treatment regimens, including a glycopeptide, either failed or were associated with significant adverse events. The good clinical outcome and the absence of significant side-effects associated with linezolid suggest that it may be an attractive alternative for the treatment of central nervous system infections, particularly in settings characterized by a high incidence of multiresistant Gram-positive pathogens.

Publication types

  • Case Reports

MeSH terms

  • Acetamides / adverse effects
  • Acetamides / therapeutic use*
  • Adult
  • Aged
  • Anti-Infective Agents / adverse effects
  • Anti-Infective Agents / therapeutic use*
  • Central Nervous System Diseases / drug therapy*
  • Central Nervous System Diseases / surgery
  • Fatal Outcome
  • Humans
  • Italy
  • Linezolid
  • Middle Aged
  • Oxazolidinones / adverse effects
  • Oxazolidinones / therapeutic use*
  • Postoperative Complications / drug therapy*

Substances

  • Acetamides
  • Anti-Infective Agents
  • Oxazolidinones
  • Linezolid