Prosthetic valve endocarditis due to vancomycin-resistant Enterococcus faecium: treatment with chloramphenicol plus minocycline

Amar Safdar; Charles S Bryan; Shawn Stinson; Donald E Saunders

doi:10.1086/340527

Prosthetic valve endocarditis due to vancomycin-resistant Enterococcus faecium: treatment with chloramphenicol plus minocycline

Clin Infect Dis. 2002 Jun 1;34(11):E61-3. doi: 10.1086/340527. Epub 2002 May 9.

Authors

Amar Safdar¹, Charles S Bryan, Shawn Stinson, Donald E Saunders

Affiliation

¹ Division of Infectious Diseases, Department of Medicine, University of South Carolina School of Medicine, Columbia, SC, 29203, USA. Safdar@richmed.medpark.sc.edu

PMID: 12015709
DOI: 10.1086/340527

Abstract

We report a case of prosthetic valve endocarditis and persistent bacteremia due to vancomycin-resistant Enterococcus faecium. The combination of parenteral chloramphenicol plus minocycline therapy was administered for 8 weeks and resulted in cure after treatment with quinupristin-dalfopristin had failed.

Publication types

Case Reports

MeSH terms

Aged
Chloramphenicol / therapeutic use*
Drug Therapy, Combination
Endocarditis, Bacterial / drug therapy*
Enterococcus faecium*
Heart Valve Prosthesis / microbiology
Humans
Male
Minocycline / therapeutic use*
Prosthesis-Related Infections / drug therapy*
Vancomycin Resistance*

Substances

Chloramphenicol
Minocycline