Abstract
Cell extracts from Yersinia pseudotuberculosis induced multinucleation in HEp-2 cells in a manner similar to the effect caused by Escherichia coli cytotoxic necrotizing factor (CNF). The activity was not dependent on the Yersinia 70-kb virulence plasmid, and the activity was not inhibited by antibodies capable of neutralizing E. coli CNF type 1. The nucleotide sequence of the Yersinia cnf gene was 65.1% identical to the E. coli cnf gene.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Bacterial Toxins / analysis*
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Bacterial Toxins / genetics
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Bacterial Toxins / toxicity
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Base Sequence
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Cytotoxins / analysis*
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Cytotoxins / genetics
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Cytotoxins / toxicity
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DNA, Bacterial / chemistry
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Escherichia coli Proteins*
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Humans
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Molecular Sequence Data
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Yersinia pseudotuberculosis / pathogenicity*
Substances
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Bacterial Toxins
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Cytotoxins
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DNA, Bacterial
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Escherichia coli Proteins
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cytotoxic necrotizing factor type 1