Mycobacterium avium infection and immune restoration disease after highly active antiretroviral therapy in a patient with HIV and normal CD4+ counts

Eur J Clin Microbiol Infect Dis. 2001 Dec;20(12):889-91. doi: 10.1007/s10096-001-0634-8.

Abstract

A patient infected with HIV who had normal CD4+ T-cell counts developed Mycobacterium avium complex lymphadenitis associated with restoration of delayed-type hypersensitivity responses to mycobacterial antigens after commencing highly active antiretroviral therapy (Mycobacterium avium immune restoration disease). This case provides further evidence that delayed-type hypersensitivity responses and CD4+ T-cell counts are independent indicators of the cellular immune defects induced by HIV infection and that Mycobacterium avium immune restoration disease may occur in patients with persistently normal CD4+ T-cell counts.

Publication types

  • Case Reports

MeSH terms

  • Antiretroviral Therapy, Highly Active*
  • CD4 Lymphocyte Count*
  • HIV Infections / complications
  • HIV Infections / drug therapy*
  • HIV Infections / immunology
  • Humans
  • Hypersensitivity, Delayed / etiology
  • Male
  • Middle Aged
  • Mycobacterium avium-intracellulare Infection / etiology*