Erythromycin and clindamycin resistance in Corynebacterium diphtheriae from skin lesions

Antimicrob Agents Chemother. 1979 Oct;16(4):525-7. doi: 10.1128/AAC.16.4.525.

Abstract

Erythromycin- and clindamycin-resistant Corynebacterium diphtheriae isolates were recovered from skin lesions. Resistance to erythromycin and clindamycin was induced by a subinhibitory concentration (0.03 microgram/ml) of erythromycin. Clindamycin (0.07 microgram/ml) was a more effective inducer of its own resistance than of erythromycin resistance. Erythromycin-inducible cross-resistance to vernamycin B alpha was demonstrated in disk diffusion tests.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Clindamycin / pharmacology*
  • Corynebacterium diphtheriae / drug effects*
  • Corynebacterium diphtheriae / isolation & purification
  • Drug Resistance, Microbial
  • Erythromycin / pharmacology*
  • Humans
  • Skin Diseases, Infectious / microbiology*
  • Time Factors

Substances

  • Clindamycin
  • Erythromycin