Enterococcal endocarditis in Sweden, 1995-1999: can shorter therapy with aminoglycosides be used?

Clin Infect Dis. 2002 Jan 15;34(2):159-66. doi: 10.1086/338233. Epub 2001 Dec 7.

Abstract

A 5-year nationwide prospective study in Sweden during 1995-1999 identified 881 definite episodes of infective endocarditis. Definite enterococcal endocarditis was diagnosed in 93 episodes (11%), the largest series of enterococcal endocarditis so far presented. Mortality during treatment was 16%, the relapse rate was 3%, and clinical cure was achieved in the remaining 81% of the episodes. Clinical cure was achieved with a median duration of cell wall-active antimicrobial therapy of 42 days combined with an aminoglycoside (median treatment time, 15 days). International guidelines generally recommend a 4-6-week combined synergistic treatment course with a cell wall-active antibiotic and an aminoglycoside. Treatment regimens in Sweden often include a shortened aminoglycoside treatment course in order to minimize adverse effects in older patients. Fatal outcome seemed not to be due to the shortened aminoglycoside therapy course. In many enterococcal endocarditis episodes, duration of aminoglycoside therapy could probably be shortened to 2-3 weeks.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aminoglycosides
  • Anti-Bacterial Agents / therapeutic use*
  • Drug Therapy, Combination
  • Endocarditis, Bacterial / diagnosis
  • Endocarditis, Bacterial / drug therapy*
  • Endocarditis, Bacterial / etiology
  • Endocarditis, Bacterial / mortality
  • Enterococcus faecalis / drug effects
  • Enterococcus faecalis / isolation & purification
  • Enterococcus faecium / drug effects
  • Enterococcus faecium / isolation & purification
  • Female
  • Gram-Positive Bacterial Infections / complications
  • Gram-Positive Bacterial Infections / diagnosis
  • Gram-Positive Bacterial Infections / drug therapy
  • Gram-Positive Bacterial Infections / mortality
  • Heart Valve Prosthesis / microbiology
  • Humans
  • Lactams
  • Male
  • Middle Aged
  • Prospective Studies
  • Secondary Prevention
  • Streptococcal Infections / complications
  • Streptococcal Infections / diagnosis
  • Streptococcal Infections / drug therapy
  • Streptococcal Infections / mortality
  • Streptococcus / drug effects
  • Streptococcus / isolation & purification
  • Sweden / epidemiology

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Lactams