Abstract
Genotypic analysis of herpes simplex virus (HSV) DNA extracted from clinical specimens from a case of fatal disseminated neonatal HSV demonstrated that an infant developed an acyclovir-resistant HSV containing a mutation in the HSV thymidine kinase gene during the first seven days of acyclovir therapy.
MeSH terms
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Acyclovir / pharmacology*
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Acyclovir / therapeutic use
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Antiviral Agents / pharmacology*
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Antiviral Agents / therapeutic use
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Autopsy
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DNA, Viral / analysis
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DNA, Viral / chemistry
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Drug Resistance, Viral
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Fatal Outcome
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Female
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Foscarnet / pharmacology
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Foscarnet / therapeutic use
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Genotype
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Herpes Simplex / drug therapy*
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Herpes Simplex / transmission
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Humans
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Immunoenzyme Techniques
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Infant, Newborn
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Infectious Disease Transmission, Vertical
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Male
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Microbial Sensitivity Tests
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Mutation
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Polymerase Chain Reaction
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Pregnancy
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Simplexvirus / drug effects*
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Simplexvirus / genetics
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Simplexvirus / isolation & purification
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Thymidine Kinase / genetics
Substances
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Antiviral Agents
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DNA, Viral
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Foscarnet
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Thymidine Kinase
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Acyclovir