Antimicrobial susceptibilities of 1,730 Haemophilus influenzae respiratory tract isolates in Spain in 1998-1999

Antimicrob Agents Chemother. 2001 Nov;45(11):3226-8. doi: 10.1128/AAC.45.11.3226-3228.2001.

Abstract

A beta-lactamase prevalence of 23% was found among 1,730 Haemophilus influenzae isolates. Ampicillin susceptibility was 70%, and 12% of beta-lactamase-negative strains presented diminished susceptibility to ampicillin (BLNAR phenotype). Susceptibility of 90% was found for cefaclor and clarithromycin, whereas it was nearly 100% for cefotaxime, cefixime, azithromycin, and cefuroxime. Ciprofloxacin-resistant (0.1%) and beta-lactamase-positive amoxicillin/clavulanate-resistant (BLPACR) phenotypes (0.1%) are anecdotal so far.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Ciprofloxacin / pharmacology
  • Haemophilus Infections / microbiology
  • Haemophilus influenzae / drug effects*
  • Haemophilus influenzae / enzymology
  • Microbial Sensitivity Tests
  • Phenotype
  • Respiratory Tract Infections / microbiology*
  • Spain
  • beta-Lactamases / biosynthesis

Substances

  • Anti-Bacterial Agents
  • Ciprofloxacin
  • beta-Lactamases