Pathogenesis of influenza A (H5N1) virus infection in a primate model

G F Rimmelzwaan; T Kuiken; G van Amerongen; T M Bestebroer; R A Fouchier; A D Osterhaus

doi:10.1128/JVI.75.14.6687-6691.2001

Pathogenesis of influenza A (H5N1) virus infection in a primate model

J Virol. 2001 Jul;75(14):6687-91. doi: 10.1128/JVI.75.14.6687-6691.2001.

Authors

G F Rimmelzwaan¹, T Kuiken, G van Amerongen, T M Bestebroer, R A Fouchier, A D Osterhaus

Affiliation

¹ Institute of Virology, National Influenza Center, Erasmus University Medical Center Rotterdam, 3000 DR Rotterdam, The Netherlands.

Abstract

Cynomolgus macaques (Macaca fascicularis) infected with influenza virus A/Hong Kong/156/97 (H5N1) developed acute respiratory distress syndrome and fever associated with a necrotizing interstitial pneumonia. Reverse transcription PCR, virus isolation, and immunohistochemistry showed that the respiratory tract is the major target of the virus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Disease Models, Animal
Fever / pathology
Immunohistochemistry
Influenza A Virus, H5N1 Subtype*
Influenza A virus* / isolation & purification
Lung Diseases, Interstitial / pathology
Lung Diseases, Interstitial / virology
Macaca fascicularis
Necrosis
Orthomyxoviridae Infections / virology*
Respiratory Distress Syndrome / pathology
Viscera / virology