Decreased susceptibility to ciprofloxacin in Salmonella enterica serotype typhi, United Kingdom

Emerg Infect Dis. 2001 May-Jun;7(3):448-50. doi: 10.3201/eid0703.010315.

Abstract

In 1999, 23% of Salmonella enterica serotype Typhi isolates from patients in the United Kingdom exhibited decreased susceptibility to ciprofloxacin (MIC 0.25-1.0 mg/L); more than half were also resistant to chloramphenicol, ampicillin, and trimethoprim. Increasing numbers of treatment failures have been noted. Most infections have been in patients with a recent history of travel to India and Pakistan.

MeSH terms

  • Anti-Infective Agents / pharmacology*
  • Ciprofloxacin / pharmacology*
  • Drug Resistance, Microbial
  • Drug Resistance, Multiple
  • Humans
  • Microbial Sensitivity Tests
  • Salmonella typhi / drug effects*

Substances

  • Anti-Infective Agents
  • Ciprofloxacin