Antimicrobial susceptibilities of unique Stenotrophomonas maltophilia clinical strains

Antimicrob Agents Chemother. 2001 May;45(5):1581-4. doi: 10.1128/AAC.45.5.1581-1584.2001.

Abstract

Susceptibility to 41 antimicrobials was studied with 99 Stenotrophomonas maltophilia strains, and different pulsed-field gel electrophoresis profiles were identified among 130 prospectively collected isolates. Moxalactam, doxycycline, minocycline, and clinafloxacin displayed the highest activity (> or = 98% susceptibility). Ticarcillin resistance (75%) was reverted by clavulanate in 25% of strains. Trimethoprim-sulfamethoxazole resistance was 26.2% (> or = 4 [trimethoprim]/76 [sulfamethoxazole] microg/ml) and dropped to 11.1% when an 8/152-microg/ml breakpoint was applied based on its bimodal MIC distribution. Resistance was lower when unique strains were considered, because clonal organisms contribute to resistance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Humans
  • Microbial Sensitivity Tests
  • Stenotrophomonas maltophilia / drug effects*
  • Stenotrophomonas maltophilia / isolation & purification

Substances

  • Anti-Bacterial Agents